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pentobarbital will reduce the level or result of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Effect of coadministering a strong CYP3A4 inducer with fedratinib hasn't been examined.pentobarbital will reduce the level or outcome of eplerenone by influencing hepatic/intestinal enzyme CYP3A